I found out that there aren't many art of the Simpsons with their genders switched, so... I made it.
From left to right:
Bert: Short for Bertha, is the family's tomboy, and causes trouble just like the boy.
Amber: It as a bit of trouble showing her baldness, so I added a hat to cover it.
Maurice: The man of the house and caring father. His hair is an afro; the beehive hairdo makes him too feminine!
Louis: The nerd with a matching red shirt and pants, and a white tie to fit.
Barry: No idea, but the bowtie is the only thing I come up.
The Simpsons (c) Matt Groening